The ASIP Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The ASIP Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Similarity: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin